Dr. Jane Welsh

Associate Professor

 


Department of Veterinary Anatomy and Public Health
Veterinary Pathobiology
Texas A&M University
College Station, TX 77843

Office: 204 VMR Building
email: jwelsh@cvm.tamu.edu 
Phone: (979) 862-4974
Fax: (979) 847-8981



Research Interests

Neuroimmunology, autoimmunity, neurotropic viruses, multiple sclerosis, blood-brain barrier, cerebrovascular endothelial cells, effects of stress on autoimmune disease

Education

B.Sc. London University, UK. Microbiology 1976
Ph.D. London University, UK Biochemistry/Immunology 1981

Recent Publications

Welsh, C.J.R., Tonks, P., Borrow, P. and Nash, A.A. (1990). Theiler's virus: an experimental model of virus-induced demyelination. Autoimmunity 6: 105-112.

Welsh, J. Neurological diseases with a presumed immune aetiology. (1990) St John's Medical Journal III: 48-52.

Borrow, P., Tonks, P., Welsh, C.J.R. and Nash, A.A. (1992). The role of CD8+ T cells in the acute and chronic phases of Theiler's virus-induced disease in mice. J. Gen. Virol. 73: 1861-1865.

Sapatino, B., Welsh, C.J.R., Smith, C.A., Bebo, B. and Linthicum D.S. (1993) Cloned mouse cerebrovascular endothelial cells that maintain their differentiation markers for Factor VIII, low density lipoprotein and angiotensin-converting enzyme. In Vitro Cell. Dev. Biol.29A: 923-928.

Welsh, C.J.R., Sapatino, B., Rosenbaum, B., Smith, R. and Linthicum, D.S. (1993) Correlation between susceptibility to demyelination and interferon gamma induction of major histocompatibility complex class II antigens on murine cerebrovascular endothelial cells. J Neuroimmunol. 48: 91-98.

Borrow, P., Welsh, C.J.R. and Nash, A.A. (1993) Study of the mechanisms by which CD4+ T cells contribute to protection in Theilers murine encephalomyelitis. Immunology 80: 502-506.

Yong, T., Bebo, B.F., Sapatino, B., Welsh, J., Orr, E.L. and Linthicum, D.S. (1994) Histamine induced microvascular leakage in pial venules: difference between SJL/j and BALB/c inbred strains of mice. Journal of Neurotrama, 11: 161-171.

Welsh, C.J.R., Sapatino, B.V., Rosenbaum, B., and Smith, R. (1995) Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection. J Neuroimmunol. 62: 119-125.

Sapatino, B.V., Petrescu, A., Rosenbaum B., Peidrahita, J., Smith, R and Welsh, C.J.R. (1995) Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. II. Persistent infection. J Neuroimmunol. 62: 127-135.

Welsh C.J.R., Sapatino, B.V., Petrescu, A., Peidrahita, J. (1995) The blood-brain barrier in virus-induced demyelination. Adv. Exp. Med. Biol., 383: 105-116.

Merriam, E.A., Campbell, B.D., Flood, L.P., Welsh, C.J.R., McDaniel, H.R. and Busbee, D.L. (1996) Enhancement of immune function utilizing a complex carbohydrate phytochemical which stimulates cytokine production and destruction of Norman Sarcoma in rodents. Advances in Anti-Aging Medicine 1, 181-203.

Walker, D.H., Popov, V.L., Crocquet-Valdes, P.A., Welsh, C.J.R. and Feng, H. (1997) Cytokine-induced, nitric oxide-dependent intracellular antirickettsial activity of mouse endothelial cells. J. Lab Invest. 76: 129-138.

Borrow, P., Welsh, C.J.R., Dean, D., Tonks, P., Blakemore, W.F., and Nash, A.A. (1998) Investigation of the role of autoimmune responses to myelin in the pathogenesis of Theiler’s virus-induced demyelinating disease. Immunology, 93, 478-484.

Qian, Y., Tiffany-Castiglioni, E., Welsh, C.J.R. and Harris, E. D. (1998) Copper efflux from murine microvascular cells requires expression of the Menkes Cu-ATPase J. Nutrition, 128, 1276-1282.

Campbell, T., Meagher, M.W., Sieve, A., Scott, B., Storts, R., Welsh, T.H. and Welsh, C.J.R. (2001) The effects of restraint stress on the neuropathogenesis of Theiler’s virus infection. I. Acute disease. Brain, Behavior and Immunity, 15, 235-254.

Tennakoon, D., Smith, R., Stewart, M.D., Spencer, T.E., Nayak, M. and Welsh, C.J.R. (2001) Ovine interferon-tau modulates the expression of MHC antigens on murine cerebrovascular endothelial cells and inhibits replication of Theiler’s virus. J. Interferon and Cytokine Research, 21, 785-792.

Girvin, A.M., Gordon, K.B., Welsh, C.J.R., Clipstone, N.A. and Miller S.D. (2002) Differential abilities of central nervous system-resident endothelial cells and astrocytes to serve as inducible APCs. Blood 99, 3692-3701.

Datta, S., Park, Y., Rangel, C., Reynolds, M.M., Caldwell, M.C., Nayak, M., Welsh, C.J.R., McDermott, S. (2002) Drosophila Perlecan transduces FGF and hedgehog signals to activate stem cell division. In press Developmental Cell.

 

Recent Grants

NIH/National Institute of Neurological Disorders and Stroke, RO1, (PI), Stress effects on an animal model of autoimmune disease, 4/1/02-3/31/06, $1,531,593.00.

National Multiple Sclerosis Society, (PI), "The effects of stress the neuropathogenesis of Theiler's virus infection", 9/30/99-8/31/02, $312,997.

Link to Vita

Link not available.



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