Fuller Warren Bazer, Ph.D.

Full Professor

Regents Fellow and O.D. Butler Chair in Animal Science
Executive Associate Dean, College of Agriculture and Life Sciences
Associate Vice Chancellor for Agriculture and Life Sciences
Associate Director Texas Agricultural Experiment Station


Animal Science and Veterinary Anatomy and Public Health
Texas A&M University
College Station, TX 77843-2471

Office: 113 Jack K. Williams Administration Building
email: fbazer@cvm.tamu.edu
Phone: (979) 458-0710
Fax: (979) 845-9938



Research Interests

Reproductive biology with emphasis on uterine biology and pregnancy. Mechanisms of action of pregnancy recognition signals from the conceptus to the maternal uterus, including interferon tau and estrogen from ruminant and pig conceptuses, respectively, are studied at the molecular and cellular levels. The roles of uterine secretions as transport proteins, regulatory molecules, growth factors and enzymes and endocrine regulation of their secretion is another major research interest. The endocrinology of pregnancy, especially the roles of lactogenic and growth hormones in fetal-placental development and uterine functions are being studied. The mechanism(s) of action and potential therapeutic value of conceptus interferons and uterine-derived hematopoietic growth factors are areas of research with both pigs and sheep as models for human disease.

Education

B.S. in Biology from Centenary College of Louisiana, 1960
M.S., Animal Science, Louisiana State University, 1963
Ph.D., Animal Science at North Carolina State University, 1969

Recent Publications

Asselin, E., Johnson, G.A., Spencer, T.E. and Bazer, F.W. Expression of monocyte chemotactic protein-1 and -2 in the ovine uterus: regulation by pregnancy, progesterone and interferon-t. Biology of Reproduction 64, 992-1000, 2001.

Barthel, R., Feng, J., Piedrahita, J.A., McMurray, D.N., Templeton, J.W. and Adams, G. Stable transfection of the bovine NRAMP1 gene into murine RAW264.7 cells: effect on Brucella abortus survival. Infection & Immunity. American Journal of Veterinary Research 61, 1140-1144, 2001.

Bazer, F.W. Genetic engineering in endocrinology: A review of genetic engineering in endocrinology edited by Margaret A. Shupnik. Trends in Endocrinology and Metabolism 12, 330-331, 2001.

Choi, Y., Johnson, G.A., Burghardt, R.C., Berghman, L.R., Joyce, M.M., Taylor, K.M., Stewart, M.D., Bazer, F.W. and Spencer, T.E. Epithelial expression of interferon regulatory factor two restricts expression of interferon-stimulated genes to the endometrial stroma and glandular epithelium of the ovine uterus. Biology of Reproduction 65, 1038-1049, 2001.

Johnson, G.A., Bazer, F.W., Jaeger, L.A., Ka, H., Garlow, J.E., Pfarrer, C., Spencer, T.E. and Burghardt, R.C. Muc-1, integrin and osteopontin expression during the implantation cascade in sheep. Biology of Reproduction 65, 820-828, 2001.

Johnson, G.A., Gray, C.A., Stewart, M.D., Choi, Y., Burghardt, R.C., Yu-Lee, L-Y, Chebath, J., Bazer, F.W. and Spencer, T.E. Effects of the estrous cycle, pregnancy and interferon tau on 2',5'-oligoadenylate synthetase expression in the ovine uterus. Biology of Reproduction 64, 1392-1399, 2001.

Johnson, G.A., Ying G-Y, Spencer, T.E.and Bazer, F.W. Isolation, immortalization and initial characterization of uterine cell lines: an in vitro model system for the porcine uterus. In Vitro Cellular and Developmental Biology 36, 650-656, 2001.

Ka, H., Jaeger, L.A., Johnson, G.A., Spencer, T.E. and Bazer, F.W. Keratinocyte growth factor is up-regulated by estrogen in the porcine uterine endometrium and functions in trophectoderm cell proliferation and differentiation. Endocrinology 142, 2303-2310, 2001.

Singh, B., Ott, T.L., Bazer, F.W. and de la Concha-Bermejillo, A. Phenotypic and ultrastructural characteristics of broncho alveolar lavage cells of lentivirus-infected lambs treated with recombinant ovine interferon-tau. Journal of Interferon and Cytokine Research 21, 677-686, 2001.

Stewart, D.M., Johnson, G.A., Vyhlidal, C.A., Burghardt, R.C., Safe, S.H., Yu-Lee, L-Y, Bazer, F.W.and Spencer, T.E. Interferon-tau (IFNtau) regulation of IFN-stimulated gene expression in cell lines lacking specific IFN-signaling components. Endocrinology 142, 1786-1794, 2001.

Stewart, M.D., Johnson, G.A., Bazer, F.W.and Spencer, T.E. Interferon-tau (IFNtau) regulation of IFN-stimulated gene expression in cell lines lacking specific IFN-signaling components. Endocrinology 142, 1786-1794, 2001.

Stewart, D.M., Johnson, G.A., Vyhlidal, C.A., Burghardt, R.C., Safe, S.H., Yu-Lee, L-Y, Bazer, F.W. and Spencer, T.E. Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells. Endocrinology 142, 98-107, 2001.

Taylor, K.M., Chen, C., Gray, C.A., Joyce, M.M., Bazer, F.W.and Spencer, T.E. Expression of mRNAs for fibroblast growth factors 7 and 10, hepatocyte growth factor and insulin-like growth factors and their receptors in the neonatal ovine uterus. Biology of Reproduction 64, 1236-1246, 2001.

Tenakoon, D., Smith, R., Stewart, M.D., Spencer, T.E., Nayak, M. and Welsh, C.J.R. Ovine IFN-tau modulates the expression of MHC antigens on murine cerebrovascular endothelial cells and inhibits replication of Theiler's virus. Journal of Interferon and Cytokine Research 21, 785-792, 2001.

Wang, G., Johnson, G.A., Spencer, T.E. and Bazer, F.W. Isolation, immortalization and initial characterization of uterine cell lines: an in vivo model system for the porcine uterus. In Vitro Cellular and Developmental Biology - Animal 36, 650-656, 2001.

Current Grants

 

Link to Vita

Link to Vita



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