Louise Abbott, PhD, DVM

Associate Professor


Veterinary Anatomy and Public Health
Veterinary Pathobiology
Texas A&M University
College Station, TX 77843

Office: 270 VMS Building
email: labbott@cvm.tamu.edu 
Phone: (979) 845-2269
Fax: (979) 847-8981
Web:http://www.cvm.tamu.edu/labbott/



Research Interests

Developmental neurobiology of the mammalian nervous system; neuroanatomy; neurochemistry; specific neurologic disorders including ataxia and epilepsy; programmed cell death (apoptosis) in the developing and adult nervous system.Toxicity of heavy metals on the developing and adult central nervous system

Education

Ph.D. University of Washington, Seattle
D.V.M., Washington State University
Post Doctoral work Washington State University

Recent Publications

Abbott, L.C. and C. Sotelo. 2000. Ultrastructural analysis of catecholaminergic innervation in weaver and normal mouse cerebellar cortices. J. Comp. Neurology 426:316-329.

Dove, L.S., Nahm, S.S., Murchison, D., Abbott, L.C. and W.H. Griffith. 2000. Altered calcium homeostasis in cerebellar Purkinje cells of leaner mutant mice. J. Neurophysiology 84:513-524.

Murchison, D., Dove, L.S., Abbott, L.C. and W.H. Griffith. 2002. Homeostatic compensation maintains C2+ signaling functions in Purkinje neurons in the leaner mutant mouse. The Cerebellum 1(2): 30-35.

Nahm, S., D. Tomlinson and L.C. Abbott. 2002. Decreased calretinin expression in cerebellar granule cells in the leaner mouse. Journal of Neurobiology 51:313-322.

Guyer, C.L., G. Stoica, J.E. Womak, R.W.Storts, J.N. Derr, and L.C. Abbott. 2002. A line of Berlin Druckerey IV rats proposed as a new model for human hereditary ataxia. In vivo 16:255-264.

Coates, J.R., D.P. O’Brien, K.L. Kline, R.W. Storts, G.C. Johnson, G.D. Shelton, E.E. Patterson,and L.C. Abbott. 2002. Neonatal Cerebellar Ataxia in Coton de Tulear Dogs. J. Vet. Internal Medicine 16:680-689.

Cicale, M., A. Ambesi-Impiombato, V. Cimini, G. Fiore, G. Muscettola, L.C. Abbott and A. de Bartolomeis. 2002. Decreased gene expression of calretinin and ryanodine receptor type 1 in tottering mice. Brain Res. Bul. 59(1):53-58.

Hsiao, S.-H., Parrish, A.R., Nahm, S.S., Abbott, L.C., McCool, B.A., and G.D. Frye. 2002. Effects of early postnatal ethanol intubation on GABAergic synaptic proteins. Devel. Brain Research 138:177-185.

Rhyu, I.J., S. Nahm, S. J. Hwang, H. Kim, Y.S. Suh, S.I. Oda, T.C. Frank and L.C. Abbott. 2003. Altered neuronal NOS expression in the cerebellum of calcium channel mutant mice. Brain Research. 977:129-140.

Frank, T.C., M. Nunley, R. Renaldo, and L.C. Abbott. 2003. Fluoro-Jade identification of cerebellar granule cell and Purkinje cell death in the a1A calcium ion channel mutant mouse, leaner. Neuroscience. 118:667-680.

Nahm, S.-S., Frank, T.C., Browning, M., Sepulvado, J., Hiney, J.K., and L.C. Abbott. 2003. Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner. Neurobiology of Disease. 14:157-165.

Current Grants

RO1-AG007805-9 (Griffith is PI)
Louise Abbott, Co-Investigator 09/01/03 - 08/31/08 (5%)
NIH-NIA $200,000 annual direct cost
Physiology of Cholinergic Basal Forebrain Neurons
The major goal of this project is to investigate the changes in calcium homeostasis and voltage channel
regulation in the aging basal forebrain.

R01-AI51493-02 (Julian Leibowitz is PI)
Louise Abbott, Co-Investigator 09/01/03 - 08/31/08 (5%)
NIH $ 175,000 annual direct cost
Interaction of MHV RNA with mtHSP70 and m-aconitase
This project will examine the effects of different proteins on murine hepatitis virus replication.

P30-EF09106 Pilot Project (Abbott is PI) 06/01/03 - 5/31/04 (10%)
Center for Environmental and Rural Health $25,000 annual direct cost
Molecular mechanisms of methylmercury toxicity

Link to Vita

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